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Heritability of complex human diseases in the UK Biobank

Monday, August 18, 2014: 6:00 PM
Bayshore Grand Ballroom E-F (The Westin Bayshore)
Maria Muņoz , The Roslin Institute and R(D)SVS, University of Edinburgh, Roslin, United Kingdom
Ricardo Pong-Wong , The Roslin Institute and R(D)SVS, University of Edinburgh, Midlothian, United Kingdom
Chris Haley , MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, United Kingdom
Albert Tenesa , The Roslin Institute and R(D)SVS & The MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Midlothian, United Kingdom
Abstract Text:

Heritabilities for the four most common human cancers were estimated using cancer prevalence among the 502,682 individuals recruited to the UK Biobank (http://www.ukbiobank.ac.uk/) and their parents. The heritability estimated from parent-offspring regressions ranged from 0.12 for lung cancer to 0.33 for prostate cancer. Our estimates were substantially smaller than previous estimates from twin studies for lung, bowel and prostate cancer whilst were similar for breast cancer, and indicate that part of the missing heritability problem in genome-wide association studies of cancer is due to twin-based heritability estimates being substantially inflated. These estimates obtained from a unique European cohort will inform future directions in cancer gene mapping and risk profiling.

Keywords:

UK Biobank

Heritability

Cancer

See more of: Symposium: Statistical Methods - Linear and Nonlinear Models: Inference
See more of: Methods and Tools: Statistical methods - linear and nonlinear models
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