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Genome-wide Association Study for Loin Marbling Score in Duroc pigs

Monday, August 18, 2014
Posters (The Westin Bayshore)
Anna Neustaeter , University of Guelph, Guelph, ON, Canada
Daniela A Grossi , Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Mohsen Jafarikia , Canadian Centre for Swine Improvement, Ottawa, ON, Canada
Mehdi Sargolzaei , The Semex Alliance, Guelph, ON, Canada
Flavio S Schenkel , Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Abstract Text: The objective of this investigation was to perform a genome-wide association study to identify chromosomal regions associated with loin marbling score (LMS) in Duroc pigs. A Generalized quasi-likelihood scoring test and a 10% false discovery rate at chromosome-wise level were used to identify the SNPs associated with LMS estimated breeding values. A total of 35 SNPs located on chromosomes 3, 5, 9, 10 and 18 were significantly associated with LMS and 47 genes were mapped either harboring or being next to these SNPs. Some of the significant SNPs were located close to or within genes (APOB, SORL1, SC5DL, FGF23, GRIK4, CLCN1) that play role in biological processes and pathways, related to lipid metabolism and fat deposition, which were significantly enriched in functional analyses. The identified genes are potential candidate genes for the underlying genetic variation in marbling score in Duroc pigs.

Keywords: candidate genes, marbling, Duroc

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