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The Effect of Inbreeding on Linkage Disequilibrium

Friday, August 22, 2014
Posters (The Westin Bayshore)
Guilherme B Nascimento , Univ. Estadual Paulista – FCAV/UNESP, Jaboticabal, Brazil
Rodrigo P Savegnago , Univ. Estadual Paulista – FCAV/UNESP, Jaboticabal, Brazil
Ricardo V Ventura , Beef Improvement Opportunities, Guelph, ON, Canada
Mônica C Ledur , Embrapa Suínos e Aves, Concórdia, Brazil
Danísio P. Munari , Universidade Estadual Paulista "Júlio de Mesquita Filho", Jaboticabal, Brazil
Abstract Text: The aim of this work was to study the linkage disequilibrium (LD) in simulated populations with different levels of inbreeding. Historical populations based on the genome of White Leghorn hens were simulated along 1023 generations allowing different historical and genetic events as bottleneck, changes on rates of females per males and mutation for SNPs and QTLs. Three different scenarios were simulated in recent populations, varying the matting type (random mating, less related or more related individuals) and heritability of traits (0.15 and 0.37) along 10 generations. The last four generations were genotyped and the LD was calculated. The heritability of the traits had no difference on the values of LD, but the inbreeding affected the effective population size (Ne) leading to different levels of LD between the populations.

Keywords:

Hens

Inbreeding

Linkage disequilibrium

Simulation