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Regional Heritability Mapping of Production Traits in Epidemic Porcine Reproductive and Respiratory Syndrome

Thursday, August 21, 2014: 10:30 AM
Bayshore Grand Ballroom A (The Westin Bayshore)
Christopher M. Orrett , The Roslin Institute and R(D)SVS, University of Edinburgh, Midlothian, United Kingdom
Nader Deeb , Genus, plc, Hendersonville, TN
Ricardo Pong-Wong , The Roslin Institute and R(D)SVS, University of Edinburgh, Midlothian, United Kingdom
Oswald Matika , The Roslin Institute and R(D)SVS, University of Edinburgh, Midlothian, United Kingdom
Craig R. G. Lewis , PIC Europe, Nantwich, United Kingdom
David G. McLaren , Genus PLC, De Forest, WI
Alan L. Archibald , The Roslin Institute and R(D)SVS, University of Edinburgh, Midlothian, United Kingdom
Stephen C. Bishop , The Roslin Institute and R(D)SVS, University of Edinburgh, Midlothian, United Kingdom
Recorded Presentation (flv)
Abstract Text:

Porcine Reproductive and Respiratory Syndrome (PRRS) is an important disease of pigs. Sow farrowing and service data were obtained from two commercial pig multiplication units which experienced several confirmed PRRS outbreaks. Genomic regions associated with reproductive failure during PRRS outbreaks were investigated using a regional heritability mapping (RHM) approach combining the two datasets. Covariates were explored both fitting and ignoring the shape of the epidemic. Heritability (h2) of farrowing mortality (FMOR, proportion of dead piglets per litter) was 0.084 ignoring the epidemic shape and 0.059 fitting it. The additive genetic variance was non-estimable for the FMOR trait during non-epidemic phase. Two regions were significantly associated with FMOR at the genome-wide level, on Sus scrofa chromosomes (SSCs) 4 and 7, with several other regions approaching significance. A single SNP on SSC4 was significantly associated (P<0.001) with FMOR.

Keywords:

Pig

PRRS

Regional Heritability Mapping

See more of: Whole Genome Scans for Disease Resistance
See more of: Genetics of Trait Complexes: Disease resistance
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