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Systems Genetics Investigations for Feed Intake, Feed Efficiency and Performance in Nellore (Bos indicus) Cattle

Thursday, August 21, 2014
Posters (The Westin Bayshore)
Miguel H A Santana , NAP-GMABT/FZEA/University of Sao Paulo, Pirassununga, Brazil
Haja N Kadarmideen , Department of Clinical Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Sameer D Pant , Department of Clinical Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Pâmela A Alexandre , NAP-GMABT/FZEA/University of Sao Paulo, Pirassununga, Brazil
Gerson A Oliveira Junior , University of São Paulo, Pirassununga, Brazil
Rodrigo C Gomes , CNPGC/EMBRAPA, Campo Grande, Brazil
Yuri T. Utsunomiya , UNESP Univ Estadual Paulista, Jaboticabal, Brazil
Haroldo HR Neves , Faculdade de Ciências Agrárias e Veterinárias – UNESP, Jaboticabal, Brazil
José F. Garcia , UNESP Univ Estadual Paulista, Araçatuba, Brazil
Heidge Fukumasu , NAP-GMABT/FZEA/University of Sao Paulo, Pirassununga, Brazil
Jose Bento Sterman Ferraz , University of Sao Paulo, Pirassununga, Brazil
Abstract Text: Genome wide association study (GWAS) was performed in 720 Nellore bulls and steers for dry matter intake (DMI), average daily gain (ADG), feed conversion ratio (FCR) and residual feed intake (RFI), using GRAMMAR-Gamma association test. Genes within 50kb flanking regions of SNPs with the highest association with the phenotypes were extracted, and pathway analysis was performed on the KEGG and DAVID databases. Several genomic regions that were significantly associated with phenotypes (p=9.27×10-5) were identified by GWAS. Near these regions, many genes were found for the four phenotypes studied (e.g. ARG2, ATP8A1, KCNJ, PLAG2G7 and ZNF746). The analysis identified three main metabolic pathways that influence the four phenotypes concomitantly. These processes are mainly related to ion transport (aldosterone-regulated sodium reabsorption), body composition (T cell receptor signaling pathway) and control of feed intake (proteoglycans).

Keywords: beef cattle, GWAS, system biology

See more of: Posters: Genetics of Trait Complexes - Feed Intake and Efficiency (Group 1)
See more of: Genetics of Trait Complexes: Feed intake and efficiency
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