094
A Genome-Wide Association Study of Immune Response in Holstein Bulls

Tuesday, August 19, 2014: 1:30 PM
Bayshore Grand Ballroom E-F (The Westin Bayshore)
Kathleen A Thompson-Crispi , Center for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Mehdi Sargolzaei , The Semex Alliance, Guelph, ON, Canada
Filippo Miglior , Center for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Flavio S Schenkel , Center for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Bonnie Mallard , Center for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Recorded Presentation (flv)
Abstract Text:

Selection for enhanced immune responsiveness using the High Immune Response Technology is a genetic approach to improve animal health. Previous genomic research has shown promise for the inclusion of immune response in genomic breeding objectives; however the research was based on a small number of cows or bulls that were selectively genotyped (n=140-168). The objective of this study was to confirm previous results on a larger sample of bulls, not selectively genotyped, with known immune response phenotypes. Immune response and 50k SNP panel genotypes for 631 Holstein bulls were included in the association study. A significant peak on chromosome 23 was found confirming previous results from the association studies using cows or bulls with extreme phenotypes for immune response. This study provides strength for the inclusion of immune response traits in genomic breeding indices to improve animal health.

Keywords:

dairy cattle

health

genomics

immune response

See more of: Variance Components and Indicators of Disease Resistance
See more of: Genetics of Trait Complexes: Disease resistance
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