096
Genetics of tolerance and resistance to nematode infection in sheep

Tuesday, August 19, 2014: 2:00 PM
Bayshore Grand Ballroom E-F (The Westin Bayshore)
Hamed Rashidi , Animal Breeding and Genomics Centre, Wageningen University, Wageningen, Netherlands
Han A. Mulder , Animal Breeding and Genomics Centre, Wageningen University, Wageningen, Netherlands
Johan A.M. van Arendonk , Animal Breeding and Genomics Centre, Wageningen University, Wageningen, Netherlands
Mart C.M. de Jong , Quantitative Veterinary Epidemiology Group, Wageningen University, Wageningen, Netherlands
Michael J. Stear , Veterinary School, Glasgow University, Glasgow, United Kingdom
Recorded Presentation (flv)
Abstract Text: We studied genetics of tolerance and resistance to nematodes in 962 Blackface lambs. A bivariate analysis was performed where tolerance was modeled as genetic effect for slope of reaction norm of bodyweight (BW) on faecal egg count (FEC) and resistance as genetic effect on levels of IgA against larvae (IgA). We observed a negative genetic correlation between BW at low and high FEC suggesting that different sets of genes control BW at low and high FEC. We observed a positive genetic correlation between BW at zero FEC level and IgA indicating that animals with high BW at zero FEC have genetically higher IgA level. We observed a negative genetic correlation between IgA and the slope of the reaction norm indicating that genetically more resistant animals are genetically less tolerant and vice versa. These results provide insight into genetics of tolerance and resistance.

Keywords:

Nematode infection

Sheep

Tolerance

Resistance

Genetics

See more of: Variance Components and Indicators of Disease Resistance
See more of: Genetics of Trait Complexes: Disease resistance
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