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Indications for presence of a major gene for thyroid cancer in German Longhaired Pointers

Friday, August 22, 2014: 10:30 AM
Cypress Room (The Westin Bayshore)
Liesbeth van der Waaij , Animal Breeding and Genomics Centre, Wageningen University, Wageningen, Netherlands
Richard Crooijmans , Animal Breeding and Genomics Centre, Wageningen University, Wageningen, Netherlands
Rebekah Keesler , Veterinary Faculty, Utrecht University, Utrecht, Netherlands
Dianne de Jong , Animal Breeding and Genomics Centre, Wageningen University, Wageningen, Netherlands
Johan de Vos , Veterinary Oncology Referral Centre ‘De Ottenhorst’, Terneuzen, Netherlands
Abstract Text: In 2010 an abnormally large number of German Longhaired Pointers (GLP) was offered for treatment of thyroid cancer. Pedigree analysis revealed a potential monogenic background. Histo-pathological examination revealed a variety of sub-types of thyroid cancer. In total 20 cases, ranging from 4.5 to 13 years old, and 28 controls were genotyped with the >170K CanineHD BeadChip. A GWAS resulted in a number of, and not in a single, genome-wide suggestive peaks. This lead to the hypothesis that there are two types of thyroid cancer in the GLP of which only one is highly heritable. When only affected dogs younger than 7 years were included in the GWAS, a single region with 5 SNP in complete LD between cases and controls was detected. This suggests the presence of a major gene that explains the onset of thyroid cancer in the German Longhaired Pointer.

Keywords:

Thyroid cancer

Dogs

Major gene

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