923
Genome-wide Association Studies on Piglet Splay leg Syndrome

Thursday, August 21, 2014
Posters (The Westin Bayshore)
Xingjie Hao , Huazhong Agricultural University, Wuhan, China
Graham S. Plastow , University of Alberta, Edmonton, AB, Canada
Chunyan Zhang , University of Alberta, Edmonton, AB, Canada
Zhiqiu Hu , University of Alberta, Edmonton, AB, Canada
Huawei Yang , Wuhan Tianzhong Stock Corporation, Wuhan, China
Wenxian Li , Wuhan Tianzhong Stock Corporation, Wuhan, China
Zhenghua Wang , Wuhan Tianzhong Stock Corporation, Wuhan, China
Zhiquan Wang , University of Alberta, Edmonton, AB, Canada
Shujun Zhang , Huazhong Agricultural University, Wuhan, China
Abstract Text: Piglet splay leg syndrome is one of the most frequent genetic defects, with affected animals having impaired ability to stand and walk. The etiology and pathogenesis of the genetic defect is complex and poorly understood. In order to identify genetic variants associated with piglet splay leg syndrome, a genome-wide association study (GWAS) was conducted to identify significant single nucleotide polymorphisms (SNPs) associated with this defect. Nine significant SNPs were detected on four chromosomes, and 108 novel candidate genes were identified based on the Sscrofa 10.2 assembly. However, validation studies in a larger set of animals, as well as gene function studies will be required for validation of the results. To our knowledge, this is the first study aiming to identify markers and genes associated with piglet splay leg syndrome by GWAS.

Keywords:

Piglet

Splay leg

Genome-wide association study

Case/control

See more of: Posters: Swine Breeding (Group 1)
See more of: Species Breeding: Swine
<< Previous Abstract | Next Abstract >>