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Association study of single nucleotide polymorphisms in STAT5A/B with mastitis susceptibility in Chinese Holstein cattle

Thursday, August 21, 2014
Posters (The Westin Bayshore)
Tahir Usman , China Agriculture University, Beijing, China
Yachun Wang , China Agriculture University, Beijing, China
Ying Yu , College of Animal Science and Technology, China Agricultural University, Beijing, China
Chao Liu , China Agriculture University, Beijing, China
Xiao Wang , China Agriculture University, Beijing, China
Yuan Zhang , China Agriculture University, Beijing, China
Abstract Text: The objective of the study was to analyze the effect of SNPs in STAT5A and STAT5B gene on some serum cytokines and mastitis traits. Total 5 SNPs were identified, including 2 in STAT5A and 3 in STAT5B gene. Fixed model was used to analyze the effects of SNPs, herd, parity, years and season of calving on the serum cytokines and mastitis indicator traits. SNP1 in STAT5A gene showed significant association with IL-6. In STAT5Bgene SNP3 was significantly associated with TNF-β, SCC and SCS, whereas, the SNP4 was significantly associated with IL-17 and IFN-γ. The dominant effect of SNP1 and the additive effects of SNP3 and SNP4 were significant on the corresponding traits on which the SNPs effect was significant. These results imply that, the SNPs significantly associated with serum cytokines and mastitis traits could be effective markers of mastitis resistance.

Keywords:

Chinese Holstein

association study

mastitis resistance

See more of: Posters: Genetics of Trait Complexes - Disease Resistance (Group 1)
See more of: Genetics of Trait Complexes: Disease resistance
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