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The Association Between Sire Estimated Breeding Value for Antibody-Mediated Immune Response (AMIR) and Offspring AMIR Phenotype

Thursday, August 21, 2014
Posters (The Westin Bayshore)
Mehdi Emam , University of Guelph, Guelph, ON, Canada
Marlene A Paibomesai , University of Guelph, Guelph, ON, Canada
Kathleen A Thompson-Crispi , Center for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Flavio S Schenkel , Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Filippo Miglior , Center for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Mehdi Sargolzaei , The Semex Alliance, Guelph, ON, Canada
Bonnie Mallard , Center for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Abstract Text: Breeding livestock for disease resistance is an attractive approach to increase animal health, longevity and profitability. Identifying dairy cattle that are more resistant to disease is now possible using High Immune Response™ (HIR) technology. Antibody-mediated immune response (AMIR), one heritable component of HIR™, was examined in a population of 1044 AMIR-tested Holsteins to investigate the effect of sire on AMIR performance of their offspring. In this population, 254 sire-offspring pairs were identified and groups of 50 high- and 50 low-responder offspring and their sires were compared.  Mean AMIR phenotype in high responder offspring was 2 SD higher than in the low group. Sires of the high responder group had mean AMIR EBV 1 SD higher than sires of the low responder group (p <0.0001). These results suggest that bulls with higher EBV for AMIR, sire offspring with higher antibody responses.

Keywords:

High immune response

Estimated breeding value

Offspring performance

See more of: Posters: Genetics of Trait Complexes - Disease Resistance (Group 1)
See more of: Genetics of Trait Complexes: Disease resistance
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