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Genome-wide Association Analyses for Mastitis in Canadian Holsteins

Thursday, August 21, 2014
Posters (The Westin Bayshore)
Daniela A Grossi , Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Mohammed K Abo-Ismail , Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Astrid Koeck , Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Stephen P Miller , AgResearch, Invermay, Mosgiel, New Zealand
Paul Stothard , University of Alberta, Edmonton, AB, Canada
Graham S. Plastow , University of Alberta, Edmonton, AB, Canada
Filippo Miglior , Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Stephen S. Moore , The University of Queensland, Queensland Alliance for Agriculture and Food Innovation, St Lucia, Australia
Mehdi Sargolzaei , The Semex Alliance, Guelph, ON, Canada
Flavio S Schenkel , Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Abstract Text: The objective of this study was to identify genomic regions associated with resistance to mastitis in Canadian Holsteins. The analyzed data contained 2,608 breeding values for mastitis and 296,672 SNPs. A generalized quasi-likelihood score test and a positive false discovery rate of 10% identified the significant SNPs. Most of the significant SNP were on chromosomes 6 (21%), 14 (21%), 16 (16%), 20 (9%), 7 (6%), and 9 (5%). The genes mapping to these regions were enriched for pathways of the immune system or lipid and carbohydrate metabolism. Results also suggest that there are additional candidate regions associated with immune system and mastitis on chromosomes 2, 3, 13, and 22.

Keywords:

immune system

genome-wide association study

heath traits

See more of: Posters: Genetics of Trait Complexes - Disease Resistance (Group 1)
See more of: Genetics of Trait Complexes: Disease resistance
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