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Angus Cattle at High Altitude: Genetic Relationships and Initial Genome-Wide Association Analyses of Pulmonary Arterial Pressure

Monday, August 18, 2014: 2:30 PM
Bayshore Grand Ballroom B-C (The Westin Bayshore)
Rebecca R Cockrum , Virginia Polytechnic Institute and State University, Blacksburg, VA
Xi Zeng , Colorado State University, Department of Animal Sciences, Fort Collins, CO
Natalie F. Berge , Colorado State University, Department of Animal Sciences, Fort Collins, CO
Joe M. Neary , Colorado State University, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, CO
Franklyn B. Garry , Colorado State University, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, CO
Tim N Holt , Colorado State University, Fort Collins, CO
Harvey D. Blackburn , USDA-ARS-National Animal Germplasm Program, Fort Collins, CO
Sean P Thomas , Colorado State University, Fort Collins, CO
Scott E. Speidel , Colorado State University, Department of Animal Sciences, Fort Collins, CO
Dorian J. Garrick , Iowa State University, Ames, IA
Richard Mark Enns , Colorado State University, Department of Animal Sciences, Fort Collins, CO
Milton G. Thomas , Colorado State University, Department of Animal Sciences, Fort Collins, CO
Recorded Presentation (flv)
Abstract Text: Records from yearling Angus (n = 10,647) cattle from elevation 2,340 m were used in genetic analysis of pulmonary arterial pressure (PAP). Bulls were developed within a grain-supplemented performance test, whereas heifers and steers were grazed. The BovineSNP50 Beadchip was used to genotype a subset of cattle (n = 1,690). Bulls had greater (P<0.001) yearling PAP values as compared to steers and heifers. Heritability ranged from 0.20 in heifers and steers to 0.31 ± 0.15 in bulls. Moderate positive genetic correlations were observed in PAP measures with heifers and bulls (0.64 ± 0.14) and steers (0.74 ± 0.37).  Genome-wide association analyses using multi-locus mixed model and Bayesian approaches revealed several QTL for PAP; however, no concordant SNP (P<0.001) were observed among males and females. Therefore, results suggest that PAP appears to be a polygenic trait influenced by sex and (or) growth. 

Keywords:

High Altitude disease

Genetic correlation

GWAS

See more of: Improving Difficult Traits in Beef Cattle
See more of: Species Breeding: Beef cattle
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