WHOLE-GENOME SCAN AND VALIDATION OF REGIONS PREVIOUSLY ASSOCIATED WITH PRRS ANTIBODY RESPONSE AND GROWTH RATE USING GILTS UNDER HEALTH CHALLENGE IN COMMERCIAL SETTINGS

Abstract Text: The genomic basis of average daily gain (ADG) and Porcine Respiratory and Reproductive Syndrome (PRRS) IgG-antibody measured by ELISA sample-to-positive ratio (S/P), was assessed in crossbred replacement gilts entering commercial farms. S/P at time of entry (S/P-d0), after acclimation (S/P-Acc), and parity 1 (S/P-Par), and ADG during acclimation were analyzed. All traits had low heritability, except S/P-Acc (0.47). Previously identified candidate SNPs for S/P on SSC7 (MARC, ASGA, M1GA, and ALGA) were validated, but effects of the SSC4 WUR SNP on S/P and growth were not significant. Two regions on SSC7 previously associated with S/P, that harbor the four candidate SNPs, were validated. One of the SSC7 regions lost its association when candidate SNPs were included in the model, indicating that these SNPs captured the effect of the region on the trait. Novel regions were associated with ADG, S/P-d0, and S/P-Acc.

Keywords:

Porcine Reproductive and Respiratory Syndrome

GWAS

genetics