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The Collaborative Cross – a next generation mouse genetic resource population for precision agriculture through deep genetic analysis
The Collaborative Cross (CC) is a mouse genetic resource for high resolution mapping of disease susceptibilities and other complex traits. The CC will consist of 600 recombinant inbred lines of which 350 are at advanced breeding generations and available for study. These lines were generated by reciprocal crosses between 8 founder lines: 5 laboratory strains, and 3 derived from wild accessions (two Mus subspecies, and one Mus domesticus). The CC resource presents extremely wide genetic diversity relative to existing mouse resources, and has shown unprecedented high resolution QTL mapping. Genotypes and phenotypes are stored centrally and are available freely, making the CC a “Genotype once, phenotype once” resource. As many diseases and complex traits (e.g., meat quality, carcass composition, dietary requirements), are common to mice and livestock, the CC resource will be a superb mouse model for genomics of agricultural animals.
Keywords:
QTL mapping
Complex traits
Disease susceptibility
