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QTL Mapping for Canine Hip Dysplasia in UK Labrador Retriever
Despite moderate heritability estimates for canine hip dysplasia (CHD), limited success has been obtained from current phenotypic selection schemes against this disorder. In this genomic analysis, two genome-wide QTLs affecting canine hip dysplasia (CHD) or its related traits were detected, and genomic evaluation (GBLUP) was implemented for a large dataset of Labrador Retrievers. The markers showing genome-wide significance explain a moderate amount of the genetic variance but the additional detection of several chromosome-wide QTLs suggests a genetic architecture based on many genes with small or moderate effect, consistent with the wide distribution of genetic variances explained by individual chromosomes. Genomic selection delivered a predictive accuracy of 0.4 for the breeding value of transformed hip score. The impact of these findings should be considered when designing future selection programs against the disease.
Keywords:
Canine hip dysplasia, Labrador Retriever, QTL.
