A genome-wide scan reveals novel loci associated with liability to scrotal and inguinal hernia in Large White pigs

Thursday, August 21, 2014
Posters (The Westin Bayshore)
Claudia Sevillano , TOPIGS Research Center IPG BV, Beuningen, Netherlands
Marcos S. Lopes , TOPIGS Research Center IPG, Beuningen, Netherlands
John W.M. Bastiaansen , Animal Breeding and Genomics Centre, Wageningen University, Wageningen, Netherlands
Barbara Harlizius , TOPIGS Research Center IPG, Beuningen, Netherlands
Abstract Text:

A genome-wide study (GWAS) was performed to identify genomic regions associated with variation in hernia liability in pigs. Breeding values were estimated for a Large White and a Landrace line based on offspring phenotypes (1,359,765 purebred and crossbred male animals) using a binary trait animal model. The incidence of hernia in the evaluated population was on average 0.42% and the heritability estimate was 0.31±0.01. Estimated breeding values were deregressed for 2,750 Large White animals that were genotyped using the Porcine SNP60 Beadchip. Deregressed estimated breeding values (DEBV) were taken as the response variable in the GWAS. The GWAS discovered 10 SNPs associated with hernia in five QTL regions. The most significant SNPs per region explained between 1.22% and 1.60% of the total phenotypic variance. Four genes (CYP19A1, RHOA, EGF, LEF1) were proposed as candidate genes for this trait.



genome wide association study