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A genome-wide scan reveals novel loci associated with liability to scrotal and inguinal hernia in Large White pigs
A genome-wide study (GWAS) was performed to identify genomic regions associated with variation in hernia liability in pigs. Breeding values were estimated for a Large White and a Landrace line based on offspring phenotypes (1,359,765 purebred and crossbred male animals) using a binary trait animal model. The incidence of hernia in the evaluated population was on average 0.42% and the heritability estimate was 0.31±0.01. Estimated breeding values were deregressed for 2,750 Large White animals that were genotyped using the Porcine SNP60 Beadchip. Deregressed estimated breeding values (DEBV) were taken as the response variable in the GWAS. The GWAS discovered 10 SNPs associated with hernia in five QTL regions. The most significant SNPs per region explained between 1.22% and 1.60% of the total phenotypic variance. Four genes (CYP19A1, RHOA, EGF, LEF1) were proposed as candidate genes for this trait.
Keywords:
hernia
genome wide association study
pigs
