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Genome-wide QTL mapping of body composition and bone mineral density traits in pigs

Friday, August 22, 2014
Posters (The Westin Bayshore)
Sophie Rothammer , Chair of Animal Genetics and Husbandry, LMU, Munich, Germany
Prisca V. Kremer , University of Applied Sciences Weihenstephan-Triesdorf, Weidenbach, Germany
Maren Bernau , Livestock Center of the Faculty of Veterinary Medicine, LMU, Munich, Germany
Ignacio Fernandez-Figares Ibanez , CSIC, Estación Experimental del Zaidín, Granada, Spain
Jennifer Pfister-Schär , Chair of Animal Genetics and Husbandry, LMU, Munich, Germany
Ivica Medugorac , Chair of Animal Genetics and Husbandry, LMU, Munich, Germany
Armin M. Scholz , Livestock Center of the Faculty of Veterinary Medicine, LMU, Munich, Germany
Abstract Text: Data of nine body composition and bone mineral density traits were obtained by dual energy X-ray absorptiometry (DXA) for 551 pigs at an age between 160 and 200 days. Additionally, all pigs were genotyped using Illumina’s PorcineSNP60 Genotyping BeadChip. Based on these data and available pedigree information a genome-wide combined linkage and linkage disequilibrium analysis (LDLA) was conducted. We used 44,611 sliding windows each consisting of 20 adjacent single nucleotide polymorphisms (SNP). The mixed linear model included random QTL effects corrected for fixed effects of sex, housing, season, age, and polygenic effects. A variance component analysis was executed in the middle of each sliding window using ASREML and likelihood ratio test statistics (LRT) were calculated. Choosing a Bonferroni corrected genome-wide significance threshold of P<0.001 (LRT=31.275) we identified 73 QTL associated with up to seven traits.

Keywords:

pig

QTL

genetics

LDLA

body composition

bone mineral density

See more of: Posters: Genetics of Trait Complexes: Growth and Development (Group 2)
See more of: Genetics of Trait Complexes: Growth and development
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