WHOLE GENOME CHARACTERIZATION AND ASSOCIATIONS STUDIES IN TWO DIVERGENT PIG LINES SELECTED ON RESIDUAL FEED INTAKE

Abstract Text: Since 2000 at INRA, two lines divergently selected for residual feed intake (RFI) have been conducted within the Large White breed. After seven generations of selection, 270 parents from the G0 to G3, and G6 generations were genotyped to (1) estimate the genomic divergence between the lines and (2) conduct a first association analysis between SNP of the Porcine60K BeadChip and performances (RFI and related trait). The results indicate that from the third generation the two lines clearly diverged at the molecular level. In view of the small size of the analysis, only two suggestive regions associated with RFI trait were detected, but genome wide significant regions were highlighted for growth, carcass composition and meat quality traits. Altogether, no large effect locus differentially retained in the divergent lines could be evidenced, suggesting that RFI is achieved through different metabolic strategies depending on the animals.

Keywords:

Pig

RFI

Association study