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Single nucleotide polymorphisms in candidate genes related to daughter pregnancy rate in Holstein cows

Thursday, August 21, 2014
Posters (The Westin Bayshore)
M. Sofia Ortega , Department of Animal Sciences, University of Florida, Gainesville, FL
Anna C Denicol , Department of Animal Sciences, University of Florida, Gainesville, FL
Daniel J Null , Animal Improvement Programs Laboratory, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD
John B Cole , Animal Improvement Programs Laboratory, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD
Peter J Hansen , Department of Animal Sciences, University of Florida, Gainesville, FL
Abstract Text:

Previously, a candidate gene approach identified 40 SNPs associated with daughter pregnancy rate (DPR) in dairy bulls. We evaluated 39 of these SNPs for relationship to DPR in a separate population of Holstein cows grouped on their predicted transmitting ability for DPR: ≤ -1 (n=1266) and ≥ 1.5 (n=1071). Genotyping was by Sequenom MassARRAY®. Of the 39 SNPs, 30 were related to DPR in the same direction as previously reported, with significance for 18. SNPs that explained the greatest proportion of variation in DPR were COQ9 (3.0%), HSD17B12 (1.6%), APBB1 (1.3%), FUT1(1.2%), and C7H19orf60(1.2%). Overall, the 39 SNPs explained 17.6% of the variation in DPR. Results indicate that a large proportion of candidate gene SNPs previously related to DPR are predictive in a separate population. Use of these SNPs may increase reliability of genomic estimates of DPR. Support: AFRI Grant No.2013-68004-20365, USDA-NIFA.

Keywords:

Daughter pregnancy rate  

Fertility

Dairy cattle

See more of: Posters: Genetics of Trait Complexes - Reproduction (Group 2)
See more of: Genetics of Trait Complexes: Reproduction
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