Bovine Spastic Paresis: A Genome-Wide Study in Fleckvieh

Abstract Text:

Bovine Spastic Paresis is a neuromuscular disorder seen sporadically in many cattle breeds. It is characterized by a progressive unilateral or bilateral hyperextension of the rear limbs. A genetic background of the trait appears unquestionable and most authors postulate recessive inheritance with incomplete penetrance. In this study we carried out a genome-wide association study including 96 AI bulls that developed spastic paresis and 4,335 matched controls. Pedigree analysis suggested a dominant mode of inheritance with incomplete penetrance. Ten SNPs showed suggestive association although not genome-wide significant.

Keywords:

cattle

spastic paresis

genome-wide association