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A genome-wide association study for resistance to viral nervous necrosis in Atlantic cod using a 12K single nucleotide polymorphism array

Thursday, August 21, 2014: 1:30 PM
Cypress Room (The Westin Bayshore)
Rama Bangera , Norwegian Institute of Food, Fisheries and Aquaculture Research, Tromsø, Norway
Matthew Baranski , Norwegian Institute of Food, Fisheries and Aquaculture Research, Tromsø, Norway
Sigbjørn Lien , Centre for Integrative Genetics, Norwegian University of Life Sciences, Ås, Norway
Abstract Text:

A genome-wide association study (GWAS) was performed for viral nervous necrosis (VNN) resistance in Atlantic cod using a polygenic (linear) mixed model approach. 704 offspring from 66 half-sib and 75 full-sib families in the Norwegian Atlantic cod breeding program were challenged tested under controlled conditions with nodavirus. The two disease traits; binary survival (BS) and number of days alive (ND) were analyzed using 8358 SNPs distributed across the Atlantic cod genome. In total, 29 and 36 genome-wide significant SNPs (P<0.0022) were detected for BS and ND, respectively. The heritability (h2) estimated using genomic kinship matrix calculated from all SNPs was high for both BS (0.49) and ND (0.81). Linkage analysis and GWAS using alternative models ar also being performed to confirm the associations discovered, and these markers have potential for applied use in MAS or genomic selection schemes.

Keywords:

Quantitative trait loci

Genome-wide association study

Polygenic model

Disease

See more of: Breeding in Aquaculture Species: Non-Salmonids
See more of: Species Breeding: Breeding in aquaculture species
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