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Optimum Contribution Selection Combined with Weighting Rare Favourable Alleles increases long-term genetic gain
the selection strategy where optimum contribution selection (OCS) are combined with genomic estimated breeding values with additional weights on rare favorable alleles (wGEBV) will boost long-term genetic gain, while at the same time effectively controlling inbreeding. Six breeding schemes were simulated by combining GEBV or wGEBV and truncation selection (TS) or OCS. Optimum contribution selection was further categorized into OCSA and OCSG depending on whether pedigree (A) or genomic data (G) was used for penalizing average co-ancestry. The selection was performed for 40 generations. It was shown that OCSG combined with wGEBV resulted in up to 38.8% higher cumulative genetic gain than TS based on GEBV, although the benefit from using wGEBV was less pronounced for OCSG than OCSA. Furthermore, the control of genome-wide inbreeding in GS can be more successfully achieved using OCSG than OCSA irrespective of selection criteria.
Keywords:
Genomic selection
Optimum contribution selection
Rare alleles
