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The Minipig Genome Harbors Regions of Selection for Growth

Monday, August 18, 2014: 5:30 PM
Bayshore Grand Ballroom A (The Westin Bayshore)
Christian H.U.W. Reimer , Georg-August-University, Göttingen, Germany
Carl-Johan Rubin , Uppsala University, Uppsala, Sweden
Steffen Weigend , Institute of Farm Animal Genetics of the Friedrich-Loeffler-Institute, Neustadt-Mariensee, Germany
Karl-Heinz Waldmann , University of Veterinary Medicine, Hannover, Germany
Ottmar Distl , University of Veterinary Medicine, Hannover, Germany
Henner Simianer , Georg-August-University, Göttingen, Germany
Recorded Presentation (flv)
Abstract Text: The whole genome resequencing (WGS) data of 46 normal sized pigs, either domestic or wild, was compared to WGS from 11 Göttingen Minipigs, 2 Berlin Minipigs, 2 Xiang pigs and one DNA pool comprising 10 Berlin Minipigs. Expected heterozygosity in the minipigs and fixation between both groups where used as a measure to find selective sweeps introduced during the selection for low body size in the minipig. 166 such candidate regions were defined and further annotated. Gene Ontology overrepresentation analysis revealed significant enrichment of terms related to growth. A large set of contained genes has been found, which have influence on i.e. growth and bone development. TGFβ and plenty of its altering genes were identified.

Keywords:

minipig

sequencing

growth

See more of: Genetics of Trait Complexes: Growth and Development
See more of: Genetics of Trait Complexes: Growth and development
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