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Mapping QTL Controlling Milk Somatic Cell Counts in Sheep and Goat Support the Polygenic Architecture the Mastitis Resistance

Thursday, August 21, 2014: 11:45 AM
Bayshore Grand Ballroom A (The Westin Bayshore)
Rupp Rachel , INRA, UMR 1388 GenPhySE, Castanet-Tolosan, France
Isabelle Palhière , INRA, UMR 1388 GenPhySE, Castanet-Tolosan, France
Carole R. Moreno , INRA, UMR1388 GenPhySE, Castanet-Tolosan, France
Gilles Foucras , ENVT-INRA, Castanet-tolosan, France
Cyrielle Maroteau , INRA, UMR1388 GenPhySE, Castanet-Tolosan, France
Aurélie Tircazes , INRA, UMR1388 GenPhySE, Castanet-Tolosan, France
Guillaume Salle , INRA, UMR1388 GenPhySE, Castanet-Tolosan, France
Guillaume Baloche , INRA, UMR 1388 GenPhySE, Castanet-Tolosan, France
Gwenola Tosser-Klopp , INRA, UMR1388 GenPhySE, Castanet-Tolosan, France
Abstract Text: QTLs for milk SCC were detected in two dairy sheep and goat designs including 1009 AI rams and 2254 Alpine and Sanen goats sired by 20 AI sires, respectively. Animals were genotyped with the 50K ovine and caprine SNP chips. Linkage and Linkage disequilibrium analyses were performed using the QTLmap software. The high number of chromosomal regions detected tended to confirm the polygenic architecture of the mastitis resistance trait. Many of these QTLs were population specific. Hence, it is difficult to tell extent to which the genetic architecture of resistance truly differs between species and breed. High significance combined to narrow confidence intervals of a few QTLs (OAR3 in sheep) and commonalties between breeds and species (OAR11 and CHI19) might help prioritizing chromosomal regions for further fine mapping and functional characterization.

Keywords: dairy sheep and goat, somatic cell count, QTL