Estimation of ancient and recent effective population size from linkage disequilibrium in a closed herd of Iberian pigs

Thursday, August 21, 2014
Posters (The Westin Bayshore)
Maria Saura , INIA, Madrid, Spain
John A. Woolliams , The Roslin Institute and R(D)SVS, University of Edinburgh, Midlothian, United Kingdom
Albert Tenesa , The Roslin Institute and R(D)SVS & The MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Midlothian, United Kingdom
Almudena Fernandez , INIA, Madrid, Spain
Beatriz Villanueva , INIA, Madrid, Spain
Abstract Text:

Effective population size is an important parameter in conservation genetics as it can help to explain patterns of genetic variation in damaged populations. Ne has been traditionally estimated from demographic data or from molecular markers based on the temporal variance of the allele frequencies that provide pointwise or average estimates over a time period. Here we have inferred ancestral and current Ne in an ancient population of Iberian pigs that is under serious danger of extinction, using information from linkage disequilibrium and recombination rate. Our results show that Ne has suffered a progressive decline through time in this population, with a critical estimate of current Ne. The availability of genome-wide genotyping platforms allows the study of populations from a more detailed perspective, providing information on the genetic status of the populations and on its evolution across time.


effective population size

linkage disequilibrium

high dense SNPs

conservation genetics