Analysis of copy number variants in Spanish authoctonous beef cattle breeds

Abstract Text: Copy number variants (CNV) are an important source of genetic and phenotypic information. They have been associated with diseases and production traits in cattle. In this work, the objective is to identify CNVs and CNV regions (CNVR) in five Autochtonous Spanish beef cattle breeds accounting 366 individuals in trios genotyped with BovineHD Beadchip. From those, we extracted the corresponding subset relative to 50K SNP array. After detection and quality filtering been applied, we identified 3,965 CNVRs in the HD array and 201 with the 50K. The total length of CNVRs covered 8.6% and 1.2% of the autosomal cattle genome, respectively. Was found segregating CNV present in more than one breed varying from 33 to 268 for the HD information and from 0 and 10 for the 50K. The interest and applicability of these results needs further investigation.

Keywords:

beef cattle

genomic

copy number variants

single nucleotide polymorphism