505
Evaluating the Effects of QTN for Milk Fat Yield and their Impact on Accuracy and Bias of Genomic Prediction in New Zealand Holstein-Friesian Cows

Monday, August 18, 2014
Posters (The Westin Bayshore)
Melanie K. Hayr , Iowa State University, Ames, IA
Mahdi Saatchi , Iowa State University, Ames, IA
Ric Sherlock , LIC, Hamilton, New Zealand
Dave Johnson , LIC, Hamilton, New Zealand
Dorian J. Garrick , Iowa State University, Ames, IA
Abstract Text:

Five SNPs were analyzed across 4,801 Holstein-Friesian cows, including three QTN for milk fat yield: DGAT1, GHR, and AGPAT6; a QTN for stature: PLAG1; and a control SNP with no effect on milk fat yield. Dominance was observed for DGAT1, AGPAT6 and PLAG1. A base model of 35,000 SNPs was run in GenSel using BayesB. In addition to the base model 1) SNP dosage was fit as a random covariate, or 2) SNP genotype was fit as a fixed covariate, or 3) SNP dosage was fit as a fixed covariate. Including these QTN as random covariates increased accuracy of direct genomic value prediction. Including QTN as fixed covariates slightly decreased accuracy and increased bias. Including DGAT1 as a fixed covariate decreased bias. These results suggest inclusion of QTN genotypes can potentially increase accuracy and decrease bias of DGV, although only slightly.

Keywords:

Milk fat

QTN

Prediction Accuracy