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Genetic Correlation and Genome Wide Association Study of Pulmonary Arterial Pressure and Post Weaning Growth Traits in Angus Heifers from a High Altitude Breeding Program

Friday, August 22, 2014
Posters (The Westin Bayshore)
Xi Zeng , Colorado State University, Department of Animal Sciences, Fort Collins, CO
Rebecca Cockrum , Virginia Polytechnic Institute and State University, Blacksburg, VA
Natalie F. Berge , Colorado State University, Department of Animal Sciences, Fort Collins, CO
Joe M. Neary , Colorado State University, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, CO
Franklyn B. Garry , Colorado State University, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, CO
Timothy N. Holt , Colorado State University, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, CO
Harvey D. Blackburn , USDA-ARS-National Animal Germplasm Program, Fort Collins, CO
Scott E. Speidel , Colorado State University, Department of Animal Sciences, Fort Collins, CO
Dorian J. Garrick , Iowa State University, Ames, IA
Richard Mark Enns , Colorado State University, Department of Animal Sciences, Fort Collins, CO
Milton G. Thomas , Colorado State University, Department of Animal Sciences, Fort Collins, CO
Abstract Text:

ABSTRACT:Elevated pulmonary arterial pressure (PAP) is an indicator trait for bovine pulmonary hypertension. The objective of this study was to determine the genetic relationship between yearling PAP (YPAP), yearling weight (YW) and post-weaning gain (PWG). Heritability and genetic correlations were estimated with data from Angus heifers at Colorado State University Beef Improvement Center (CSU-BIC) using a multivariate animal model. A genome-wide association study was performed for each trait using univariate models. The estimated heritabilities of YPAP, YW and PWG were 0.22 ± 0.04, 0.43 ± 0.04 and 0.28 ± 0.04, respectively. Genetic correlations between YPAP and YW or PWG were low and positive (0.22 ± 0.04 and 0.04 ± 0.12, respectively). There were no genome windows associated with both YPAP and either weight trait. Selection for post-weaning growth should not lead to increased risk of high PAP in Angus heifers.

Keywords:

Pulmonary arterial pressure

Growth traits

Genetic relationship

See more of: Posters: Adaptation and Selection in Harsh Environments (Group 2)
See more of: Genetic Improvement Programs: Selection for harsh environments and management of animal genetic resources
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