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Genomic Analysis of the Spring Leg Defect in the Canadian Dorset Sheep Breed
Genomic Analysis of the Spring Leg Defect in the Canadian Dorset Sheep Breed
Tuesday, August 19, 2014
Posters (The Westin Bayshore)
Abstract Text:
Planned matings were carried out to produce 150 Dorset lambs and validate the hypothesis of a genetic determinism for the spring leg defect in sheep. Two groups of lambs were produced through planned matings; one at risk of developing spring leg and one at low risk of developing the defect. In the high risk group, 23.1% of the lambs developed the defect, versus 3.4% in the low risk group. A total of 192 sick and normal animals were genotyped with the ovine 600K SNP panel, and association studies were carried out between SNP genotypes and the expression of the defect. Three promising SNPs were detected on chromosome 24, showing polymorphisms significantly associated with the spring leg defect.
Keywords:
sheep
spring leg
GWAS