Hierarchical Quantitative Genetic Model Using Genomic Information

Abstract Text:

Genomic evaluations are commonly based on models with genomic relationships. However, estimated genomic relationship matrices are often positive semi-definite and ad-hoc corrections are applied to force positive definiteness without consideration about model properties. In this contribution a hierarchical quantitative genetic model is postulated that provides a positive definite genomic relationship matrix by taking into account the amount of genetic variance captured by estimated marker effects. Based on the hierarchical formulation the proposed model also provides a system of equations to estimate marker effects and breeding values jointly without setting up and inverting covariance matrices. Further extension with pedigree information is also possible.

Keywords:

genomics

hierarchical model

inverse