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Genome-wide analysis of the differential response to experimental challenges with Porcine Circovirus 2b

Tuesday, August 19, 2014: 1:30 PM
Bayshore Grand Ballroom B-C (The Westin Bayshore)
Taylor Engle , University of Nebraska-Lincoln, Lincoln, NE
Erin Jobman , University of Nebraska-Lincoln, Lincoln, NE
Tim Moural , University of Nebraska-Lincoln, Lincoln, NE
Autumn McKnite , University of Nebraska-Lincoln, Lincoln, NE
Sarah Barnes , University of Nebraska-Lincoln, Lincoln, NE
Emily Davis , University of Nebraska-Lincoln, Lincoln, NE
Jessica Qiu , University of Nebraska-Lincoln, Lincoln, NE
Justin Bundy , University of Nebraska-Lincoln, Lincoln, NE
Julie Tart , University of Nebraska-Lincoln, Lincoln, NE
Theresa Johnson , University of Nebraska-Lincoln, Lincoln, NE
Max F. Rothschild , Iowa State University, Ames, IA
Judith Galeota , University of Nebraska-Lincoln, Lincoln, NE
Rodger K. Johnson , University of Nebraska - Lincoln, Lincoln, NE
Graham Plastow , University of Alberta, Edmonton, AB, Canada
Stephen D. Kachman , University of Nebraska - Lincoln, Lincoln, NE
Daniel C. Ciobanu , University of Nebraska - Lincoln, Lincoln, NE
Abstract Text:

Porcine Circovirus 2 (PCV2) is the causative source of a group of associated diseases (PCVAD) that affects production efficiency and can lead to mortality. Using commercial crossbred pigs (n=974) experimentally infected with PCV2b we analyzed genetic sources of the variation in PCVAD susceptibility. A genome-wide association study including 56,433 SNPs uncovered two major SNPs that explain 11.5% (SSC12) and 2.8% (SSC7) respectively, of the genetic variation for viral load. These SNPs partially explained the negative correlations between viral load and ADG during challenge (r=-0.36, P<0.0001). The CC genotype of the SNP located on SSC12 was associated with lower viral load (P<0.0001) and higher overall ADG (P<0.05) compared to CT and TT genotypes. These genetic variants influence the ability of the host to react and influence PCV2b replication and immune response and improve general animal health and welfare while reducing production costs.

Keywords: PCV2, Genetic Susceptibility, Genome-wide association study.

See more of: Symposium: Genomics of Disease in Swine
See more of: Species Breeding: Swine
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