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Association Of A Bovine Chromosome 19 Region, 51 Mb, With The Variation Of Oleic Acid In Hanwoo
Carcass samples of 450 Hanwoo steers were collected in the Livestock Research Institute, Ansung, Korea, to detect SNP markers that were significantly associated with oleic acid (C18:1). The bovine Affymetrix 640K beadchip array was used for the SNP genotyping to perform genome-wide association tests. Analyses were performed using the Bayes B model implemented in the Gensel software. Three chromosomal regions, 51Mb of BTA19, 9 Mb of BTA24, and 54Mb of BTA5 were detected for C18:1 with 21.7%, 3.7% and 1.5% of total genetic variance, respectively. At the BTA19 region, a SNP (C/T), AX-21950207 that was located at 51,333kb was detected with 96% posterior probability of inclusion, which was distal to the FASN gene location (51,385~51,404 Kb). Additional studies are needed to verify the SNP effect on oleic acid variability between Hanwoo carcasses and to find the causal mutation at the chromosomal region.
Keywords:
Hanwoo
Oleic acid
SNP
GWAS
