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The relationship of OPP infection to TMEM154 genotype in a Midwestern sheep flock

Tuesday, August 19, 2014
Posters (The Westin Bayshore)
Thomas W. Murphy , University of Wisconsin-Madison, Department of Animal Sciences, Madison, WI
David L. Thomas , University of Wisconsin-Madison, Department of Animal Sciences, Madison, WI
Todd A Taylor , University of Wisconsin-Madison, Department of Animal Sciences, Madison, WI
Michael J Maroney , University of Wisconsin-Madison, Research Animal Resources Center, Madison, WI
Kay M Nelson , University of Wisconsin-Madison, Research Animal Resources Center, Madison, WI
Abstract Text: Ovine progressive pneumonia (OPP) is an incurable, progressive, viral disease of sheep caused by a lentivirus affecting the lungs, udder, nervous system, and joints. The objective of this study was to determine the relationship between OPP status (POS or NEG) and TMEM154 genotype in Hampshire (H) and Polypay (P) ewes from the university flock at the Arlington Agricultural Research Station. Incidence of POS ewes was 55.9% and 41.9% among H and P ewes, respectively. Frequencies of TMEM154 haplotypes across both breeds were 0.77, 0.13, 0.04, and 0.06 for haplotypes 1, 2, 3, and 4, respectively. Within and across breeds, ewes with 1 or 2 copies of haplotype 2 or 3 had a higher incidence of OPP than ewes of diplotype 1,1; in agreement with previous studies on genetic susceptibility to OPP. Producers wishing to decrease susceptibility to OPP infection should select 1,1 TMEM154 diplotype animals.

Keywords:

Sheep

TMEM154

Lentivirus

See more of: Posters: Sheep and Goats Breeding (Group 3)
See more of: Species Breeding: Sheep and goats
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