Diet Complexity Affects Post-weaning Performance and Immune Response to Porcine Circovirus 2 (PCV2) Infection in Nursery Pigs
Tuesday, March 18, 2014: 1:45 PM
314-315 (Community Choice Credit Union Convention Center)
To investigate the effects of complex and prebiotic diets on nursery pigs inoculated for or vaccinated against PCV2 on growth performance and immune parameters, 96 weaned barrows (age 27 to 40 d; BW 7.1 kg) were housed (4 pigs/pen) in an environmentally-controlled nursery with ad libitum access to feed and water over a 28-d study. Forty-eight pigs were vaccinated (VAC) for PCV2 prior to arrival, while remaining pigs (PCV) were inoculated for PCV2 on d 0. Pigs were randomly assigned to 1 of 3 diets: complex (CO; lactose, spray-dried plasma, spray-dried whey), simple (SI; corn and SBM), or simple + 2.5% Grobiotic-S (GS). Blood samples were obtained twice per week (d -2 to 28) for serum cytokine and PCV2-specific immunoglobulin (Ig) G and M quantification. No significant time, diet, or PCV-status interactions were observed for growth performance. Body weight tended (P < 0.06; d 14 to 28) to be greater in VAC (11.1 to 18.4 kg) compared to PCV (10.3 to 16.7 kg) pigs, and overall ADG (P < 0. 04) and ADFI (P < 0.03) were greater in VAC (0.40 kg and 0.68 kg, respectively) compared to PCV (0.35 kg and 0.61kg, respectively) pigs. Overall, pigs fed CO (0.71 kg) had greater (P < 0.02) ADFI compared to GS (0.61 kg) pigs and tended (P < 0.08) to be greater than SI (0.63 kg) pigs. Pigs fed CO (0.60) had greater (P < 0.05) G:F (d 0 to 7) compared to GS (0.46) and SI (0.51); however, G:F (P < 0.05; d 21 to 28) was decreased in CO (0.59) pigs compared to SI (0.67) pigs. For IgG, a diet x PCV-status interaction was observed (P < 0.04); PCV pigs fed SI and GS had increased PCV2-specific IgG (P < 0.05) compared to CO pigs. No effects of PCV-status or diet were observed with respect to IL-12p40, IL-6, IL-8, IL-10, or TNF-α; however, main effects of PCV-status (IFN-α; P < 0.01) and diet (IL-1β; P < 0.03) were observed. Specifically, greater IFN-α was observed for PCV compared to VAC pigs on d 11 (P < 0.02) and 14 (P < 0.02), and pigs fed CO had greater overall IL-1β compared to GS (P < 0.04) and SI (P < 0.02). Results indicate a complex nursery diet may improve post-weaning growth performance and affect immune response to PCV2 infection.
Keywords: health, pig, PCV2