595
Genome-wide Linkage Disequilibrium Linkage Analysis (LDLA) of Body Fat Traits in an F2 Porcine Model for Human Obesity

Friday, August 22, 2014
Posters (The Westin Bayshore)
Sameer D Pant , Department of Clinical Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Peter K Mortensen , Department of Clinical Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Susanna C Salicio , Department of Clinical Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Lisette JA Kogelman , Department of Clinical Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Mette J Jacobsen , Department of Clinical Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Camilla S Bruun , Department of Clinical Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Claus B Jørgensen , Department of Clinical Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Theo H. E. Meuwissen , Department of Animal and Aquacultural Sciences, University of Life Sciences, Ås, Norway
Haja N Kadarmideen , Department of Clinical Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Merete Fredholm , Department of Clinical Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Abstract Text: Purebred Duroc and Yorkshire sows were crossed with Göttingen minipig boars to obtain two separate F2 intercross resource populations (n=287 and 279 respectively). Several obesity, metabolic and slaughter measurements were recorded from birth to slaughter (220±45 days). In addition, body composition was determined at about two months of age (64±11 days) via dual-energy x-ray absorptiometry (DXA) scanning. All pigs were genotyped using Illumina Porcine 60k SNP Beadchip and a combined LDLA approach was used to perform genome-wide linkage and association analysis for body fat traits. Subsequently bioinformatic analysis was performed to identify genes in close proximity of chromosomal positions where statistically significant QTLs were identified. Several important genes previously linked to obesity (e.g. BBS4, CHRNA2, DLK1), along with other novel genes were identified, that together provide novel insights that may further the current understanding of the molecular mechanisms underlying human obesity.

Keywords: LDLA, Pig model, QTL mapping

See more of: Posters: Genetics of Trait Complexes: Growth and Development (Group 2)
See more of: Genetics of Trait Complexes: Growth and development
Previous Abstract | Next Abstract >>