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Local Score Based Method Applied On Pool-Sequenced Behavior-Divergent Lines Precisely Detected Selection Signatures Related To Autism In Quail

Tuesday, August 19, 2014
Posters (The Westin Bayshore)
María Inés Fariello Rico , INRA, UMR1388 GenPhySE, Castanet-Tolosan, France
Simon Boitard , GABI (INRA / AgroParisTech), Jouy-en Josas, France
Sabine Mercier , Université Toulouse Le Mirail, Toulouse, France
David Robelin , INRA, UMR1388 GenPhySE, Castanet-Tolosan, France
Thomas Faraut , INRA, UMR1388 GenPhySE, Castanet-Tolosan, France
Cécile Arnould , INRA, UMR85 Physiologie de la Reproduction et des Comportements, Nouzilly, France
Elisabeth Lebihan , INRA, UR83 Recherches Avicoles, Nouzilly, France
Julien Recoquillay , INRA, UR83 Recherches Avicoles, Nouzilly, France
Gerald Salin , INRA, UMR1388 GenPhySE, Castanet-Tolosan, France
Patrice Dehais , INRA UMR1388 GenPhySe, Castanet-Tolosan, France
Frederique Pitel , UMR 1388 INRA / INPT ENSAT / INPT ENVT, GenPhySE, Castanet-Tolosan, France
Christine Leterrier , INRA, UMR85 Physiologie de la Reproduction et des Comportements, Nouzilly, France
Magali SanCristobal , INRA, UMR1388 GenPhySE, Castanet-Tolosan, France
Abstract Text:

Detecting genomic footprints of selection is an important step in the understanding of evolution. Accounting for haplotype information in genome scans for selection allows increasing the detection power, but haplotype-based methods require individual genotypes and are not applicable when only allele frequencies are available. We propose here to take advantage of the local score approach to accumulate (possibly small) signals from single markers over a genomic segment, to clearly pinpoint a selection signal. This method gave results similar to haplotype-based methods on benchmark data sets with individual genotypes. Results obtained for a divergent selection experiment on behavior in quail, where two lines were sequenced in pools, are precise and biologically coherent. This local score approach is general and can be applied to other genome-wide analyzes such as GWAS or genome scans for selection.

Keywords:

Footprint of selection

Local score

Quail