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A New Method to Estimate Recombination Rate Based on SNP Allelic Dosage Data
SNP allelic dosage data have been widely used in SNP genotyping and many other analyses. Here we proposed a new method to estimate the recombination rate between SNPs using this kind of data. This method exploits sperm samples from only one male animal, and extracts linkage information from the sperm cells. It is established on the principle of recombination and the statistical distributions of alleles. The method has power to simultaneously capture the recombination information on the entire genome from a larger amount of sperm cells, and estimate the individual-level recombination rate. Simulation studies showed that this method is very accurate and precise because of the integration of a large amount of information. This method has implication for constructing fine linkage maps, which has potential to be further used in genome analysis and research areas such as recombination hotspots.
Keywords:
Recombination rate
SNP dosage data
