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Fine-mapping of a candidate region associated with milk-fat composition on Bos Taurus Autosome 17

Wednesday, August 20, 2014
Posters (The Westin Bayshore)
Sandrine I Duchemin , Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
Marleen H.P.W. Visker , TI Food and Nutrition, Wageningen, Netherlands
Johan A.M. van Arendonk , Animal Breeding and Genomics Centre, Wageningen University, Wageningen, Netherlands
Henk Bovenhuis , Animal Breeding and Genomics Centre, Wageningen University, Wageningen, Netherlands
Abstract Text:

ABSTRACT. A genomic region associated with milk-fat composition has been detected on BTA17. However, no candidate gene or causal variant has been identified so far. Our goal was to fine-map this region by using imputed 777k SNP genotypes. Phenotypes and genotypes were available on 1,581 animals. Phenotypes consisted of gas chromatography measurements of C8:0, and genotypes consisted of the imputed 777k SNP. Single SNP analyses were run using an animal model to retrieve significant SNP. Based on these SNP, haplotypes were constructed. Haplotypes suggested the presence of one QTL within the fine-mapped region. This QTL explained 9% of the genetic variation in C8:0. Although many genes are present in this QTL region, most of these genes have not been characterized yet. Therefore, no clear candidate gene associated with milk-fat composition could be identified.

Keywords:

Cattle

Milk fatty acids

High density genotyping

See more of: Posters: Genetics of Trait Complexes - Lactation
See more of: Genetics of Trait Complexes: Lactation
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