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A Genome Wide Association Analysis Confirms a Complex, Polygenic Determinism of Resistance to Salmonella Carrier-State in Chicken
Salmonella Enteritidis is a threat to human health due to the consumption of contaminated meat or eggs. A genome wide association study was performed using a 60 K SNP chip to identify genomic regions associated with resistance to salmonella carrier-state. We genotyped 209 chicks issued from an F8 advanced intercross line between two experimental inbred lines and experimentally infected with S. Enteritidis. Their carrier-state was assessed by measuring the fecal count of S. Enteritidis 4 weeks after infection. After quality controls, 22,557 markers could be used for a genome wide association analysis performed with the plink software. Half of the markers associated with the highest probabilities were located in genomic regions previously identified for their association with resistance to S. Enteritidis carrier-state or resistance to S. Typhimurium in chicken. This study therefore confirms and refines the location of several regions of interest.
Keywords:
Chicken; Salmonella Enteritidis; GWAS
