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Genome Wide Association Analyses Identify New Loci for Milking Speed and Temperament in North American Holsteins

Friday, August 22, 2014: 4:15 PM
Bayshore Grand Ballroom A (The Westin Bayshore)
Mohammed K Abo-Ismail , Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Stephen P Miller , AgResearch, Invermay, Mosgiel, New Zealand
Mehdi Sargolzaei , The Semex Alliance, Guelph, ON, Canada
Daniela A Grossi , Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Shadi Nayeri , University of Alberta, Edmonton, AB, Canada
Stephen S. Moore , The University of Queensland, Queensland Alliance for Agriculture and Food Innovation, St Lucia, Australia
Graham S. Plastow , University of Alberta, Edmonton, AB, Canada
Paul Stothard , University of Alberta, Edmonton, AB, Canada
Flavio S Schenkel , Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada
Abstract Text: The objectives of this study were to identify significant genomic regions for Milking Speed (MS) and Milking Temperament (MT) and run an in silico functional analysis for the corresponding genes. Genome-wide association studies were performed using a generalized quasi-likelihood score test, using BovineSNP50 Bead-Chip genotypes from 2,363 and 2,270 Holstein bulls with proofs for MS and MT, respectively. A total of 601 and 406 SNPs were associated with MS and MT at 5% chromosome-wise false discovery rate, respectively. A total of 301 genes were found to overlap with 353 of the significant SNPs for both traits. A total of 1,308 genes were enriched (P<0.05) in 12 pathways. This study confirmed previously reported QTL and suggested new positional candidate genes. The predictive ability of the significant SNPs will be investigated to validate the candidate genes and biological mechanisms associated with MS and MT.

Keywords: Genome wide association study, Milkability traits

See more of: Genetics of Trait Complexes - Lactation
See more of: Genetics of Trait Complexes: Lactation
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