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Preliminary identification and characterization of copy number variations in the genome of South African Nguni cattle
Preliminary identification and characterization of copy number variations in the genome of South African Nguni cattle
Friday, August 22, 2014: 11:00 AM
Bayshore Grand Ballroom D (The Westin Bayshore)
Abstract Text: Copy number variations (CNVs) are modifications in DNA structure comprising of deletions, duplications and insertions. The prevalence of CNVs in South African cattle populations is largely unknown. South African Nguni cattle are recognized for their ability to sustain harsh environmental conditions while exhibiting enhanced resistance to disease and parasites. The underlying genetic components thereof, are however not yet understood. Illumina BovineSNP50 Beadchip data was utilized to investigate CNVs in 56 South African Nguni bulls using PennCNV software. 436 copy number variation regions (CNVRs) are reported. CNVRs ranged from 44kb to 62Mb in size. 81% of CNVs were enriched for genes involved in a variety of functions including immune and cellular processes. CNVs may explain part of the phenotypic diversity and enhanced adaptation evident in Nguni cattle. The exact mechanisms and effects of such CNVRs however must still be determined.
Keywords:
Copy Number Variation
Nguni cattle
Bovine SNP50K
