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Analysis Of Biological Pathways Associated With Immune-capacity Traits In Pig

Thursday, August 21, 2014
Posters (The Westin Bayshore)
Toshihiro Okamura , Tohoku University, Aoba-ku, Sendai City, Japan
Youichi Takahagi , Nippon Meat Packers, Inc. R&D Center, Tsukuba, Japan
Toshimi Matsumoto , National Institute of Agrobiological Sciences, Tsukuba, Japan
Hirohide Uenishi , National Institute of Agrobiological Sciences, Tsukuba, Japan
Keiichi Suzuki , Tohoku University, Aoba-ku, Sendai City, Japan
Masahiro Satoh , NARO Institute of Livestock and Grassland Science, Tsukuba, Japan
Abstract Text: The aim of this study was to estimate pathways that are associated with immune-capacity traits in large white pigs. Using 564 pigs, three immune-capacity traits associated with single nucleotide polymorphism (SNP) genotypes were examined. The immune-capacity traits included phagocyte activity (PA), complement alternative pathway activity (CAPA), and antibody production against the swine erysipelas vaccine (AP). A genome-wide association study was performed and SNPs with P-values <0.01 were identified for each trait. To identify candidate genes affecting each trait, 1-Mb windows centered on each detected SNP were examined for concordance. The candidate genes for each trait were assembled into pathways using an online database, and several pathways were estimated. Pathway analysis revealed that “p53 signaling pathway” and “apoptosis” were related to CAPA and that “complement and coagulation cascades” was related to AP.

Keywords:

pig

disease resistance

pathway analysis

See more of: Posters: Genetics of Trait Complexes - Disease Resistance (Group 1)
See more of: Genetics of Trait Complexes: Disease resistance
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