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Long-term selection for litter size results in significant shifts in allelic frequency in regions involved in reproductive processes

Thursday, August 21, 2014
Posters (The Westin Bayshore)
Melanie D. Trenhaile , University of Nebraska - Lincoln, Lincoln, NE
Jessica L. Petersen , University of Minnesota, Saint Paul, MN
Katharine L. Lucot , University of Nebraska - Lincoln, Lincoln, NE
Stephen D. Kachman , University of Nebraska - Lincoln, Lincoln, NE
Rodger K. Johnson , University of Nebraska - Lincoln, Lincoln, NE
Daniel C. Ciobanu , University of Nebraska - Lincoln, Lincoln, NE
Abstract Text: Genetic structure based on high-density genotypes was analyzed in three genetic lines of swine that express substantial variation in litter size traits to uncover regions of the genome that displayed shifts in allelic frequency possibly due to selection. The experimental lines include the Nebraska Index Line (NIL) and a control line (CTRL), both originating from the same Large White by Landrace composite population, and a Duroc by Hampshire (DxH) commercial line. NIL underwent long-term selection for litter size traits, while no selection for litter size was practiced in CTRL and DxH. Regions that displayed significant changes in SNP heterozygosity and significant differences in allelic frequency between populations were identified. Many of these regions overlapped with significant QTL for litter size traits identified by genome-wide association studies and contained candidate genes involved in various reproductive processes.

Keywords:

swine

selective sweep

reproductive traits

See more of: Posters: Swine Breeding (Group 2)
See more of: Species Breeding: Swine
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