648
Genome wide association study for calving interval in Gyr dairy cattle

Thursday, August 21, 2014
Posters (The Westin Bayshore)
Marco A. Machado , Embrapa Dairy Cattle, Juiz de Fora, Brazil
Adam T. H. Utsunomiya , UNESP Univ Estadual Paulista, Jaboticabal, Brazil
Solomon A. Boison , University of Natural Resources and Life Sciences, Vienna, Austria
Daniel J. A. dos Santos , State University of São Paulo, Faculty of Agriculture and Veterinary Sciences, Jaboticabal, Brazil
Yuri T. Utsunomiya , UNESP Univ Estadual Paulista, Jaboticabal, Brazil
Ricardo da Fonseca , São Paulo State University “Júlio de Mesquita Filho", Dracena, Brazil
Johann Sölkner , University of Natural Resources and Life Sciences, Vienna, Austria
José F. Garcia , UNESP Univ Estadual Paulista, Araçatuba, Brazil
Rui S. Verneque , Embrapa Dairy Cattle, Juiz de Fora, Brazil
Marcos V. G. B. da Silva , Embrapa Dairy Cattle, Juiz de Fora, Brazil
Abstract Text:

We used the Heterocedastic Effects Model (HEM) to perform a genome-wide scan for loci affecting calving interval in Gyr dairy cattle. HEM is an extension of SNP-BLUP that allows for marker-specific shrinkages in order to improve QTL mapping. The 20 SNPs with the largest estimated effects accounted for 1.32% of the total additive genetic variance. In particular, markers rs41888601 and rs137830830 are located on the chromosome domains encompassing SMG9, SLC39A11 and SOX, which are known to be involved in oestrus cycle and fertility. As HEM relaxes the penalization of large effects SNPs, the low percentage of additive genetic variance explained by these markers brings further evidence that calving interval is highly polygenic and controlled by many QTLs.

Keywords:

GWAS

calving interval

HEM model

Gyr

See more of: Posters: Genetics of Trait Complexes - Reproduction (Group 2)
See more of: Genetics of Trait Complexes: Reproduction
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