Effect of prototype sequestering agents on performance and milk aflatoxin M1 concentrations of dairy cows fed aflatoxin B1-contaminated diets

Ogunade, Ibukun

1838
Effect of prototype sequestering agents on performance and milk aflatoxin M1 concentrations of dairy cows fed aflatoxin B1-contaminated diets

Wednesday, July 23, 2014

Exhibit Hall AB (Kansas City Convention Center)

Ibukun M Ogunade , University of Florida, Department of Animal Sciences, Gainesville, FL

Kathy G. Arriola , University of Florida, Department of Animal Sciences, Gainesville, FL

Rafael M Martins , University of Florida, Department of Animal Sciences, Gainesville, FL

Bibiana Y Coy , University of Florida, Department of Animal Sciences, Gainesville, FL

Chelsea L Curry , Dept. of Animal Sciences, University of Florida, Gainesville, FL

Deborah K Terkoski , University of Florida, Department of Animal Sciences, Gainesville, FL

Amber Rubright , University of Florida, Department of Animal Sciences, Gainesville, FL

Marcos G Zenobi , Dept. of Animal Sciences, University of Florida, Gainesville, FL

Zhengxin Ma , Dept. of Animal Sciences, University of Florida, Gainesville, FL

Charles R Staples , Dept. of Animal Sciences, University of Florida, Gainesville, FL

Adegbola T Adesogan , Dept. of Animal Sciences, University of Florida, Gainesville, FL

Abstract Text:

This study examined if 3 in-feed mycotoxin-sequestering agents could reduce milk aflatoxin M₁ (AFM₁)concentration and improve the performance and immunological responses of dairy cattle fed diets contaminated with aflatoxin B₁(AFB₁). Fifteen lactating cows were used in a 5 × 5 Latin square design with four 28-d periods and 3 replicate squares. Treatments included a Control diet (C), a toxin (T) diet containing 75 ug of AFB₁/kg of TMR DM and 3 diets containing T and one of three prototype sequestering agents (S1, S2, and S3). The AFB₁was mixed with corn and molasses and dosed in gelatin capsules orally to cows before the TMR was fed on d 21 to 25. Milk was sampled twice daily on d 20 to 28 and plasma was sampled on d 20 and 25. The statistical model contained effects of diet, period, square, appropriate interactions and cow nested within square. Feeding T increased the milk AFM₁ concentration beyond the FDA safety threshold (0.5 ug/kg) and values were greater (P < 0.001) than those in cows fed C. Sequestering agents (S1, S2 and S3) did not reduce the transfer of AFB₁to AFM₁. Feeding T reduced (P = 0.03) milk fat (0.93 vs. 1.05 kg/d) and protein (0.78 vs. 0.89 kg/d) yield and tended (P = 0.09) to reduce milk fat (3.74 vs. 3.84%) and protein (3.12 vs. 3.24%) concentrations compared to C. Feeding sequestering agents prevented these reductions in yields and concentrations of milk components except that S3 reduced milk fat yield. Cows fed S3 had lower (P = 0.01) DMI and greater (P = 0.01) feed efficiency (FCM/DMI; 1.34 vs. 1.12) than those fed C. Feeding T instead of C reduced (P < 0.05) red blood cell counts and hemoglobin concentration. Plasma acid-soluble protein concentration and monocyte counts were lower (P < 0.05) in cows fed S1, S2 and S3 compared to those fed T reflecting attenuation of the immunological challenge posed by feeding AFB₁. Sequestering agents had no effect on milk AFM₁concentration but prevented adverse effects of AFB₁onmilk component yields and concentrations and immunological response indices

Keywords:

Milk

Mycotoxin

Sequestering agents

1838 Effect of prototype sequestering agents on performance and milk aflatoxin M1 concentrations of dairy cows fed aflatoxin B1-contaminated diets

1838
Effect of prototype sequestering agents on performance and milk aflatoxin M1 concentrations of dairy cows fed aflatoxin B1-contaminated diets