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Effect of supplying a nucleotide product (NuPro) to sow diets on growth performance and immune response of the offspring in the nursery
Effect of supplying a nucleotide product (NuPro) to sow diets on growth performance and immune response of the offspring in the nursery
Tuesday, March 17, 2015
Grand Ballroom - Posters (Community Choice Credit Union Convention Center)
Abstract Text:
Nucleotides have reported benefits in diets for young mammals. Studies have demonstrated their ability to alter several biological responses, including improving growth and immunity, during stress periods. Experiments 1 was conducted to evaluate the effect of dietary supplementation of nucleotides to late gestating sows on the performance of the piglets during nursery. Sows (n = 37) were randomly assigned to 2 dietary treatments: 1) a corn-soybean meal control diet or 2) the control diet with 1% soybean meal replaced by NuPro® (NT; 44% CP, ~6% total nucleic acids; Alltech Inc.). The dietary treatments were started about d 101-102 of gestation and continued throughout lactation. At weaning, piglets (n = 104) from sows on each diet were split into 2 groups and fed diets that contained 0 or 2.5% NT to replace soybean meal in a 28-d study which resulted in a 2 x 2 factorial arrangement. The data were analyzed using GLM program of SAS. Supplying NT to sow diets had no effect on litter size, litter weight, or mortality at birth and weaning (P > 0.20). In the nursery, there was no difference in piglet body weight, daily gain, or daily feed intake. However, pigs that consumed the NT diet (regardless of the sow treatment) tended to have numerically decreased feed:gain ratio than control pigs at Wk 2 (P = 0.11; 1.42 vs. 1.62), Phase 1 (P = 0.17, 1.25 vs. 1.42), and the total period (P = 0.12; 1.43 vs. 1.52). Experiment 2 was conducted to investigate the effect of NT on the immunocompetence of weaned pigs. Piglets (n = 64) from sows not fed NT were fed the same diets as Experiment 1. There was no difference between treatments in the growth performance during the 28-d study. After the 28-d study, pigs were challenged with either phosphate buffered saline (PBS) or a lipopolysaccharide (LPS) solution. For the LPS-challenged pigs, those consumed NT diets tended to lose less weight (P < 0.08; -0.34 vs -0.98 kg) and consumed more feed (P < 0.04; 0.39 vs 0.26 kg) within 24 hours post-challenge. Serum TNF-α concentration at 2h post-injection (P < 0.01; 4,470 vs 10,873 pg/mL) and serum IL-6 concentration at 4h post-injection (P < 0.03; 4,590 vs 14,649 pg/mL) were also decreased in NT-fed pigs than in control pigs. In conclusion, adding NT to the nursery diets had limited effects on growth in the relatively clean environment of these studies. However, dietary NT supplementation reduced weight loss and altered aspects of the immune response in a disease-challenge model.
Nucleotides have reported benefits in diets for young mammals. Studies have demonstrated their ability to alter several biological responses, including improving growth and immunity, during stress periods. Experiments 1 was conducted to evaluate the effect of dietary supplementation of nucleotides to late gestating sows on the performance of the piglets during nursery. Sows (n = 37) were randomly assigned to 2 dietary treatments: 1) a corn-soybean meal control diet or 2) the control diet with 1% soybean meal replaced by NuPro® (NT; 44% CP, ~6% total nucleic acids; Alltech Inc.). The dietary treatments were started about d 101-102 of gestation and continued throughout lactation. At weaning, piglets (n = 104) from sows on each diet were split into 2 groups and fed diets that contained 0 or 2.5% NT to replace soybean meal in a 28-d study which resulted in a 2 x 2 factorial arrangement. The data were analyzed using GLM program of SAS. Supplying NT to sow diets had no effect on litter size, litter weight, or mortality at birth and weaning (P > 0.20). In the nursery, there was no difference in piglet body weight, daily gain, or daily feed intake. However, pigs that consumed the NT diet (regardless of the sow treatment) tended to have numerically decreased feed:gain ratio than control pigs at Wk 2 (P = 0.11; 1.42 vs. 1.62), Phase 1 (P = 0.17, 1.25 vs. 1.42), and the total period (P = 0.12; 1.43 vs. 1.52). Experiment 2 was conducted to investigate the effect of NT on the immunocompetence of weaned pigs. Piglets (n = 64) from sows not fed NT were fed the same diets as Experiment 1. There was no difference between treatments in the growth performance during the 28-d study. After the 28-d study, pigs were challenged with either phosphate buffered saline (PBS) or a lipopolysaccharide (LPS) solution. For the LPS-challenged pigs, those consumed NT diets tended to lose less weight (P < 0.08; -0.34 vs -0.98 kg) and consumed more feed (P < 0.04; 0.39 vs 0.26 kg) within 24 hours post-challenge. Serum TNF-α concentration at 2h post-injection (P < 0.01; 4,470 vs 10,873 pg/mL) and serum IL-6 concentration at 4h post-injection (P < 0.03; 4,590 vs 14,649 pg/mL) were also decreased in NT-fed pigs than in control pigs. In conclusion, adding NT to the nursery diets had limited effects on growth in the relatively clean environment of these studies. However, dietary NT supplementation reduced weight loss and altered aspects of the immune response in a disease-challenge model.
Keywords: Nucleotide, nursery, immunity