Effects of Mycotoxin Contaminated High Protein Distillers Dried Grains (HP-DDG) and Mycotoxin Mitigation Additive on Growth Performance and Plasma GLP-1 Concentration of Growing-Finishing Pigs

The objective of this study was to investigate the effects of feeding HP-DDG contaminated with a mixture of mycotoxins and a possible mitigation on growth performance and plasma glucagon-like peptide-1 (GLP-1) of growing-finishing pigs. Pigs (144 mixed sex, initial BW = 25 ± 2 kg) were fed either a corn soybean meal control diet (CON; n = 8) or a 30% HP-DDG diet (n = 8) containing 0.7 mg/kg deoxynivalenol, 0.1 mg/kg fumonisins, and 56 µg/kg zearalenone for 8 wk. On wk 9, a mycotoxin mitigation intervention was applied using a blend of preservatives containing sodium metabisfulfite (PB; Defusion Plus, Provimi North America Inc., OH) resulting in 4 groups: CON, CON + 0.25% PB, 30% HP-DDG, and 30% HP-DDG + 0.25% PB. A 4-phase feeding program was used and diets within phases were formulated to contain equal standardized ileal digestible Lys:ME. Growth performance data were collected once every two wk and blood samples from 2 pigs/pen with weight closest to pen mean were collected on wk 8, and at the end of the experiment (wk 16) for plasma GLP-1 analysis. Data were analyzed using a mixed model with block as a random effect, and diet, and day × diet as fixed effects. Overall, in the first 8 wk, pigs fed HP-DDG had less ADG (0.75 vs. 0.83 kg/d; P < 0.01) and ADFI (1.69 vs. 1.84 kg/d; P < 0.01) compared with CON. After intervention was applied at the start of wk 9, pigs fed HP-DDG had lower overall ADG compared with pigs fed HP-DDG+PB (0.90 vs. 0.96 kg/d; P < 0.05), but not compared with CON (0.90 vs. 0.92 kg/d; P > 0.05). There were no differences in ADG between groups fed CON, CON+PB and HP-DDG+PB (P > 0.05). The HP-DDG group also had lower overall ADFI compared with CON (2.81 vs. 2.63 kg/d; P < 0.05), but there were no differences among groups fed with PB or CON (P > 0.05). Final BW for pigs fed HP-DDG (109.5 kg) was less (P < 0.05) than the pigs fed CON (115.1 kg), CON+PB (116.4 kg), and HP-DDG + PB (113.6 kg). There were no differences in plasma GLP-1 levels among treatments (P > 0.05) in spite differences in ADFI. Collectively, naturally occurring mycotoxins in HP-DDG had significant negative effects on ADG and ADFI but supplementation of PB alleviated those effects.