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The influence of host's genetics on the gut microbiota composition in pigs and its links with immunity traits

Monday, August 18, 2014: 5:30 PM
Bayshore Grand Ballroom B-C (The Westin Bayshore)
Jordi Estellé , INRA, UMR1313 GABI, Jouy-en-Josas, France
Núria Mach , INRA, UMR1319 MICALIS, Jouy-en-Josas, France
Yuliaxis Ramayo-Caldas , INRA, UMR1313 GABI, Jouy-en-Josas, France
Florence Levenez , INRA, UMR1319 MICALIS, Jouy-en-Josas, France
Gaëtan Lemonnier , INRA, UMR1313 GABI, Jouy-en-Josas, France
Catherine Denis , INRA, UMR1313 GABI, Jouy-en-Josas, France
Joël Doré , INRA, UMR1319 MICALIS, Jouy-en-Josas, France
Catherine Larzul , INRA, UMR1313 GABI, Jouy-en-Josas, France
Patricia Lepage , INRA, UMR1319 MICALIS, Jouy-en-Josas, France
Claire Rogel-Gaillard , INRA, UMR1313 GABI, Jouy-en-Josas, France
Abstract Text:

The objective of this study was to estimate the genetic parameters of the gut microbiota composition and study the links with immunity traits (ITs) in French Large White pigs. A cohort of 60-days old piglets was assessed for fecal microbiota composition by pyrosequencing of the 16S rDNA. First results on 299 piglets showed a predominance of Prevotella followed by Oscillibacter, Dialister, Roseburia and Treponema. Among a set of 63 genera, 7 had low (0.1<h2<0.2), 15 medium (0.2<h2<0.4) and 8 high (h2>0.4) heritabilities for abundance variations. At the genetic level, the relative abundance of Prevotella, Oribacterium, Selenomonas, Dialister and Megasphaera are correlated positively with each other and tend to be negatively correlated to other genera. Finally, canonical correlation (rCCA) and sPLS analyses highlighted both positive and negative correlations between various ITs (e.g. monocytes, eosinophils, platelets) and genera such as Prevotella, Roseburia and Dialister.

Keywords: pig; gut microbiota; immunity

See more of: Symposium: Omics and Swine
See more of: Species Breeding: Swine
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