359
Genome wide perspective of genetic variation in pig metabolism and production traits

Monday, August 18, 2014: 5:45 PM
Bayshore Grand Ballroom B-C (The Westin Bayshore)
Luca Fontanesi , Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy
Samuele Bovo , Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy
Gianluca Mazzoni , Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy
Antonia Bianca Samorè , Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy
Giuseppina Schiavo , Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy
Emilio Scotti , Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy
Flaminia Fanelli , Department of Surgical and Medical Sciences, Endocrinology Unit, University of Bologna, Bologna, Italy
Francesca Bertolini , Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy
Maurizio Gallo , ANAS, Roma, Italy
Luca Buttazzoni , Consiglio per la Ricerca e la Sperimentazione in Agricoltura - Centro di Ricerca per la Produzione delle Carni e il Miglioramento Genetico, Roma, Italy
Giuliano Galimberti , Department of Statistical Sciences “Paolo Fortunati”, University of Bologna, Bologna, Italy
Daniela Giovanna Calò , Department of Statistical Sciences “Paolo Fortunati”, University of Bologna, Bologna, Italy
Marco Mezzullo , Department of Surgical and Medical Sciences, Endocrinology Unit, University of Bologna, Bologna, Italy
Pier Luigi Martelli , Biocomputing Group, University of Bologna, Bologna, Italy
Rita Casadio , Biocomputing Group, University of Bologna, Bologna, Italy
Uberto Pagotto , Department of Surgical and Medical Sciences, Endocrinology Unit, University of Bologna, Bologna, Italy
Vincenzo Russo , Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy
Stefania Dall'Olio , Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy
Abstract Text: In this study we present a first genomics-metabolomics approach in pigs. About 900 performance tested Italian Large White pigs were genotyped with the Illumina PorcineSNP60 BeadChip. Blood was collected at slaughtering for haematological analyses. Plasma was used for the determination of 186 metabolites using mass spectrometry. Performance and carcass traits were measured on the same animals. Heritability of  metabotypes and haematological parameters ranged from 0.04 to 0.93. A Graphical Gaussian Model (GGM) was generated including partial correlation coefficients. The structure of the obtained network represented clearly the general biological relationships among metabolites. GGM analyses suggested that pig metabolism is very close to the human metabolism.  Genome wide association studies, carried out for a total of 153 traits, identified genetic variation in genes directly involved in the metabolism of several metabolites that could open interesting applications in pig nutrigenomics.

Keywords:
metabolomics
systems biology
genome wide association study

See more of: Symposium: Omics and Swine
See more of: Species Breeding: Swine
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